Manageiro, VeraFerreira, EugéniaAlmeida, JoanaBarbosa, StephanieSimões, ConstançaBonomo, Robert A.Caniça, Manuela2016-03-222016-03-222015Antimicrob Agents Chemother. 2015;59(6):3588-92. doi: 10.1128/AAC.05065-14. Epub 2015 Mar 16.0066-4804http://hdl.handle.net/10400.18/3720Free PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432220/Among the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn4401d-blaKPC-3, 4 intI3-blaGES-5, and one intI1-blaVIM-2 gene, alone or in combination with other bla genes. The dissemination of blaKPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.engResistência aos AntibióticosCarbapenemasesKPC-3PortugalEnterobacteriaceaejournal article10.1128/AAC.05065-14