Chen, GongboGuo, YumingYue, XuTong, ShiluGasparrini, AntonioBell, Michelle L.Armstrong, BenSchwartz, JoelJaakkola, Jouni J.K.Zanobetti, AntonellaLavigne, EricNascimento Saldiva, Paulo HilarioKan, HaidongRoyé, DominicMilojevic, AiOvercenco, AlaUrban, AlešSchneider, AlexandraEntezari, AlirezaVicedo-Cabrera, Ana MariaZeka, ArianaTobias, AurelioNunes, BaltazarAlahmad, BarrakForsberg, BertilPan, Shih-ChunÍñiguez, CarmenAmeling, CarolineDe la Cruz Valencia, CésarÅström, ChristoferHouthuijs, DannyVan Dung, DoSamoli, EvangeliaMayvaneh, FatemehSera, FrancescoCarrasco-Escobar, GabrielLei, YadongOrru, HansKim, HoHolobaca, Iulian-HoriaKyselý, JanTeixeira, João PauloMadureira, JoanaKatsouyanni, KleaHurtado-Díaz, MagaliMaasikmets, MarekRagettli, Martina S.Hashizume, MasahiroStafoggia, MassimoPascal, MathildeScortichini, Matteode Sousa Zanotti Stagliorio Coêlho, MichelineValdés Ortega, NicolásRyti, Niilo R.I.Scovronick, NoahMatus, PatriciaGoodman, PatrickGarland, Rebecca M.Abrutzky, RosanaGarcia, Samuel OsorioRao, ShilpaFratianni, SimonaDang, Tran NgocColistro, ValentinaHuber, VeronikaLee, WhanheeSeposo, XerxesHonda, YasushiGuo, Yue LeonYe, TingtingYu, WenhuaAbramson, Michael J.Samet, Jonathan M.Li, Shanshan2022-07-052022-07-052021-09Lancet Planet Health. 2021 Sep;5(9):e579-e587. doi: 10.1016/S2542-5196(21)00200-X.2542-5196http://hdl.handle.net/10400.18/8063Background: Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world. Methods: For this time series study, data on daily counts of deaths for all causes, cardiovascular causes, and respiratory causes were collected from 749 cities in 43 countries and regions during 2000-16. Daily concentrations of wildfire-related PM2·5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0·25° × 0·25° resolution. The association between wildfire-related PM2·5 exposure and mortality was examined using a quasi-Poisson time series model in each city considering both the current-day and lag effects, and the effect estimates were then pooled using a random-effects meta-analysis. Based on these pooled effect estimates, the population attributable fraction and relative risk (RR) of annual mortality due to acute wildfire-related PM2·5 exposure was calculated. Findings: 65·6 million all-cause deaths, 15·1 million cardiovascular deaths, and 6·8 million respiratory deaths were included in our analyses. The pooled RRs of mortality associated with each 10 μg/m3 increase in the 3-day moving average (lag 0-2 days) of wildfire-related PM2·5 exposure were 1·019 (95% CI 1·016-1·022) for all-cause mortality, 1·017 (1·012-1·021) for cardiovascular mortality, and 1·019 (1·013-1·025) for respiratory mortality. Overall, 0·62% (95% CI 0·48-0·75) of all-cause deaths, 0·55% (0·43-0·67) of cardiovascular deaths, and 0·64% (0·50-0·78) of respiratory deaths were annually attributable to the acute impacts of wildfire-related PM2·5 exposure during the study period. Interpretation: Short-term exposure to wildfire-related PM2·5 was associated with increased risk of mortality. Urgent action is needed to reduce health risks from the increasing wildfires.Evidence before this study: Many regions of the world are now facing more frequent and unprecedentedly large wildfires. Wildfire-related air pollution has become a major public health concern, as it can travel widely and cause various adverse health effects. Previous studies have found wildfire-related air pollution to be significantly associated with increased mortality risk. We searched PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure using the terms “wildfire”, “bushfire”, “fine particulate matter”, “fine particles”, “PM2·5”, “death”, and “mortality” in English and Chinese for studies published up to Dec 25, 2020. We identified several studies exploring the impact of wildfire-related PM2·5 on mortality. These studies showed that wildfire-related PM2·5 had adverse effects on all-cause, cardiovascular, and respiratory mortality. However, the existing evidence comes from single-city or single-region studies, and not from studies with global reach. Added value of this study: To the best of our knowledge, this is the largest study evaluating associations between acute wildfire-related PM2·5 and mortality, and the first to do so comprehensively across various regions of the world, using daily death count data between 2000 and 2016 from 749 cities in 43 countries and regions. We found that the pooled relative risks of mortality associated with a 10 μg/m3 increase in the 3-day moving average of wildfire-related PM2·5 concentrations were 1·019 (95% CI 1·016–1·022) for all-cause mortality, 1·017 (1·012–1·021) for cardiovascular mortality, and 1·019 (1·013–1·025) for respiratory mortality. Overall, 0·62% (95% CI 0·48–0·75) of all-cause deaths, 0·55% (0·43–0·67) of cardiovascular deaths, and 0·64% (0·50–0·78) of respiratory deaths were attributable to the acute impacts of wildfire-related PM2·5 exposure during the study period. Implications of all the available evidence: This study provides robust epidemiological evidence of the acute effects from wildfire-related PM2·5 exposure on mortality, based on a large multicountry dataset and standard statistical method. Policy makers and public health professionals should raise awareness of wildfire pollution to prompt public responses and take actions to avoid exposure.engMortality RiskWildfirePM 2·5 PollutionDeterminantes da Saúde e da DoençaGenotoxicidade Ambientaljournal article10.1016/S2542-5196(21)00200-X