Leal, BárbaraChaves, JoãoCarvalho, CláudiaRangel, RuiSantos, AgostinhoBettencourt, AndreiaLopes, JoãoRamalheira, JoãoSilva, Berta M.da Silva, António MartinsCosta, Paulo P.2018-03-222021-12-162017-12-15J Neuroimmunol. 2017 Dec 15;313:82-88. doi: 10.1016/j.jneuroim.2017.10.014. Epub 2017 Nov 60165-5728http://hdl.handle.net/10400.18/5430Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.engAdultBrainCytokinesEpilepsy, Temporal LobeFemaleHLA-DR AntigensHumansMaleMicrogliaMiddle AgedToll-Like Receptor 4Young AdultDoenças Genéticasjournal article10.1016/j.jneuroim.2017.10.014