Louro, HenriquetaVasconcelos, Ana LuisaPenque, DeborahSilva, Maria João2018-08-162018-08-162018-07-04http://hdl.handle.net/10400.18/5600The use of chemicals in a wide spectrum of applications from biomedicine to agriculture has brought undeniable benefits to society. However, it is also important to assess, control and minimize potential costs, in terms of long-term impacts on human health and the environment quality. In order to enable chemicals risk assessment and management based on scientific evidence, it is crucial to know the real exposure of citizens to chemicals as well as their adverse effects on human health. In addition, within the framework of chemicals risk assessment, hazard characterization through in vitro and in vivo studies is also central. In this context, the team has developed biomonitoring and molecular epidemiology studies aimed at exploring interactions between occupational or environmental stressors and the human genome/proteome, as determinants of human diseases. Among these, the characterization of biological effects from occupational exposure to second-hand smoke and the effects of uranium mines and its residues on the population health will be presented to highlight their relevance for public health and environment policies. The results of an ongoing study focused on the genotoxicity of the chemical Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), which has been applied as a non-aromatic plasticizer to replace other hazardous phthalate plasticizers will illustrate the additional need of toxicological studies for a comprehensive assessment of the potential adverse effects of chemicals on human health. Finally, the objectives of the European Biomonitoring Initiative - HBM4EU (https://www.hbm4eu.eu/) aimed at filling the knowledge gaps and promoting innovative approaches in the area of human exposure to chemicals will be presented, as an example of a multidisciplinary and integrative programme that is expected to support the formulation of better environment and health policies to protect human health.engHuman BiomonitoringGenotoxicidade Ambientalconference object