Gonçalves, VâniaMatos, PauloPereira, JoanaHenriques, AndreiaJordan, Peter2019-02-142020-06-012018-11http://hdl.handle.net/10400.18/5822Distinct genetic subtypes have been described in colon cancer, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogeneinduced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells.engColon CancerAlternative SplicingRAC1bSignal TransductuionVias de Transdução de Sinal e Patologias Associadasconference object10.1097/MD.0000000000015772