Stucki, DavidBrites, DanielaJeljeli, LeïlaCoscolla, MireiaLiu, QingyunTrauner, AndrejFenner, LukasRutaihwa, LilianaBorrell, SoniaLuo, TaoGao, QianKato-Maeda, MidoriBallif, MarieEgger, MatthiasMacedo, RitaMardassi, HelmiMoreno, MilagrosVilanova, Griselda TudoFyfe, JanetGloban, MariaThomas, JacksonJamieson, FrancesGuthrie, Jennifer L.Asante-Poku, AdwoaYeboah-Manu, DorothyWampande, EddieSsengooba, WillyJoloba, MosesBoom, W. HenryBasu, IndiraBower, JamesSaraiva, MargaridaVasconcellos, Sidra E.G.Suffys, PhilipKoch, AnastasiaWilkinson, RobertGail-Bekker, LindaMalla, BijayaLey, Serej D.Beck, Hans-Peterde Jong, Bouke C.Toit, KadriSanchez-Padilla, ElisabethBonnet, MarylineGil-Brusola, AnaFrank, MatthiasPenlap Beng, Veronique N.Eisenach, KathleenAlani, IssamNdung'u, Perpetual WanguiRevathi, GunturuGehre, FlorianAkter, SuriyaNtoumi, FrancineStewart-Isherwood, LynseyNtinginya, Nyanda E.Rachow, AndreaHoelscher, MichaelCirillo, Daniela MariaSkenders, GirtsHoffner, SvenBakonyte, DaivaStakenas, PetrasDiel, RolandCrudu, ValeriuMoldovan, OlgaAl-Hajoj, SahalOtero, LarissaBarletta, FrancescaCarter, E. JaneDiero, LameckSupply, PhilipComas, IñakiNiemann, StefanGagneux, Sebastien2022-02-092022-02-092016-10-31Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 311061-4036http://hdl.handle.net/10400.18/7943Rita Macedo - INSAGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.engDNA, BacterialGenomicsGenotypeGlobal HealthHumansMycobacterium tuberculosisPhylogeographyPolymorphism, GeneticTuberculosisInfecções Respiratóriasjournal article10.1038/ng.3704