A Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compounds

Hevia, AranchaRuas-Madiedo, PatriciaFaria, Miguel AngeloPetit, ValérieAlves, BrunaAlvito, PaulaArranz, ElenaBastiaan-Net, ShannaCorredig, MilenaDijk, WienekeDupont, DidierGiblin, LindaGraf, Brigitte AnnaKondrashina, AlinaRamos, HelenaRuiz, LorenaSantos-Hernández, MartaSoriano-Romaní, LauraTomás-Cobos, LidiaVivanco-Maroto, Santiaga MaríaRecio, IsidraMiralles, Beatriz2024-01-222024-01-222023-11-30J Agric Food Chem. 2023 Dec 13;71(49):19265-19276. doi: 10.1021/acs.jafc.3c05479. Epub 2023 Nov 30. Review0021-8561http://hdl.handle.net/10400.18/8948ReviewAssessing nutrient bioavailability is complex, as the process involves multiple digestion steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro models of different physiological relevance are used to study nutrient absorption, providing significant challenges in data evaluation. However, such in vitro models are needed for mechanistic studies as well as to screen for biological functionality of the food structures designed. This collaborative work aims to put into perspective the wide-range of models to assay the permeability of food compounds considering the particular nature of the different molecules, and, where possible, in vivo data are provided for comparison.engFood CompoundsIntestinesNutrient BioavailabilityTransepithelial TransportTransporte TransepitelialIntestinoToxicologiaSegurança AlimentarA Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compoundsjournal article10.1021/acs.jafc.3c05479