Ferreira, R.Leal, B.Chaves, J.M.M.Carvalho, C.Bettencourt, A.Freitas, J.Ramalheira, J.E.D.P.Lopes, J.M.C.F.Martins da Silva, A.Costa, P.P.Silva, B.2019-04-012019-04-012018-06uropean Journal of Neurology. 2018;25(Suppl. 2):226http://hdl.handle.net/10400.18/6356Background and aims: Brain-derived neurotrophic factor (BDNF) is a neurothrophin associated with a wide range of neurophysiological processes, such as neurogenesis, gliogenesis, synaptogenesis and neuroprotection. BDNF has been described as overexpressed in hippocampus of both animal models and Mesial Temporal Lobe Epilepsy (MTLE) patients. Gene expression may be modulated by DNA methylation of the respective promoter regions. We sought to analyze, the DNA methylation of the BDNF exon I promoter, a region associated with neuronal imbalanceengBrain-derived Neurotrophic FactorDoenças Genéticasconference object