Feliciano, AméliaTorres, Vukosava M.Vaz, FatimaCarvalho, Ana SofiaMatthiesen, RunePinto, PaulaMalhotra, AtulBárbara, CristinaPenque, Deborah2015-06-262015-06-262015-04Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 141389-9457http://hdl.handle.net/10400.18/3093Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.engSleep ApneiaObstructive Sleep ApneaBiomarkersProteomicsMass SpectrometryLungMetabolic DisordersGenomica FuncionalGenómica Funcional e Estruturaljournal article10.1016/j.sleep.2014.11.014