Functional compatibility of PB1 and antigenic proteins as a determinant of viral fitness and adaptation in the A(H1N1)pdm09

Gíria, MartaLouro, JoãoRebelo de Andrade, Helena2017-03-142017-03-142016-08http://hdl.handle.net/10400.18/4637Objectives: To determine if the functional compatibility between PB1 and antigenic proteins is a molecular determinant of virus growth and antigen yield in PR8:A(H1N1)pdm09 reassortants; To evaluate the phenotypic expression of reverting mutations R386K, I517V and L298I, previously identified as putatively associated with an enhanced functional compatibility between PB1 and HA in the A(H1N1)pdm09engPB1Antigenic ProteinsInfluenza VirusA(H1N1)pdm09InfluenzaInfecções RespiratóriasFunctional compatibility of PB1 and antigenic proteins as a determinant of viral fitness and adaptation in the A(H1N1)pdm09conference object