Correia, Ana M.Borges, VítorIsidro, JoanaLima, Ana R.Fernandes, AlbertoGodinho, Maria LeonorDuarte, SílviaFerrão, JoséVieira, LuísGomes, João P.2022-07-042022-07-042021-09-20Int J Infect Dis. 2021 Nov;112:318-320. doi: 10.1016/j.ijid.2021.09.035. Epub 2021 Sep 20.1201-9712http://hdl.handle.net/10400.18/8055Re-positivity of SARS-CoV-2 tests is widely reported, raising discussion about guidance for patient discharge and ending isolation. The unsuccessful recovery of replication-competent virus and/or absence of secondary cases has suggested that re-positive patients are not contagious. This study reports SARS-CoV-2 re-positivity in a healthcare professional 16 days after three negative tests, with viral genome sequencing supporting contagiousness leading to secondary cases.Highlights: - SARS-CoV-2 re-positivity tests are widely reported; Re-positive patients are assumed not to be contagious; Genome sequencing supported contagiousness from a re-positive patient to contacts.engCOVID-19Genome SequencingInfectivityRe-positivitySARS-CoV-2Infecções RespiratóriasCuidados de Saúdejournal article10.1016/j.ijid.2021.09.035