Marques, RitaLacerda, RafaelaRomão, Luísa2023-01-252023-01-252022Encyclopedia. 2022:26365. Review2309-3366http://hdl.handle.net/10400.18/8458ReviewThis entry is adapted from 10.3390/biomedicines10081865 (http://repositorio.insa.pt/handle/10400.18/8440)Internal ribosome entry site (IRES)-mediated translation is an alternative mechanism of translation initiation, known for maintaining protein synthesis when canonical translation is impaired. During a stress response, it contributes to cell reprogramming and adaptation to the new environment.engInternal Ribosome Entry SiteIRES Trans-acting FactorsIRES-based Multicistronic VectorsAntisense OligonucleotidesNeurodegenerative DiseasesMuscular AtrophiesExpressão GénicaGenómica Funcional e Estruturalbook part