Teixeira-Gomes, ArmandaLage, BrunaEsteves, FilipaSousa, Ana CatarinaPastorinho, M. RamiroValdiglesias, VanessaCosta, SolangeLaffon, BlancaTeixeira, João Paulo2021-04-082021-04-082020-05-05Toxicol Lett. 2020 May 5;330:14-22. doi: 10.1016/j.toxlet.2020.04.023. Online ahead of print.0378-4274http://hdl.handle.net/10400.18/7669Frailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The study population was classified as 45.1% robust, 45.1% pre-frail and 9.8% frail. A significant higher prevalence of second-hand smokers was found in the pre-frail group when compared to robust. Furthermore, a higher prevalence of robust individuals was found among those consuming home-produced vegetables and water from well/springs. Significant differences were found between data collected in a lifetime exposure questionnaire (LTEQ) and the levels of genotoxicity endpoints and the mercury levels analysed regarding some exposure-related parameters, namely, smoking habits, intake of home-produced vegetables and the use of pesticides in agriculture. Understanding if the way we live(d) or worked can impact the way we age are important questions to be explored. Data obtained in this pilot study encourage further studies on this matter, exploring the role of exposures history and its impact on health.Highlights: Frailty is an age-related syndrome expected to increase over the next years; A prevalence of second-hand smokers was found in the pre-frail group; Home-produced vegetables consumers had lower %TDNA levels; Exposure-related factors should be included when studying disease aetiology; The way we live(d) or worked may have an impact on the way we age.engDNA DamageExposure HistoryFrailtyH2AX PhosphorylationMercuryGenotoxicidade Ambientaljournal article10.1016/j.toxlet.2020.04.023