Bernauer, UlrikeBodin, LaurentChaudhry, QasimCoenraads, Pieter JanEzendam, JanineGaffet, EricGalli, Corrado L.Panteri, EiriniRogiers, VeraRousselle, ChristopheStepnik, MaciejVanhaecke, TamaraWijnhoven, SusanBenfenati, EmilioCorsini, EmanuelaKoutsodimou, AglaiaAglaia KoutsodimouLouro, HenriquetaUter, Wolfgangvon Goetz, Natalie2025-11-112025-11-112025-07-04NAM Journal. 2025;1:100035. doi: 10.1016/j.namjnl.2025.100035. Correction: NAM Journal. 2025 Oct 14: 100059. doi:10.1016/j.namjnl.2025.100059http://hdl.handle.net/10400.18/10584Correction: NAM Journal. 2025 Oct 14: 100059. doi:10.1016/j.namjnl.2025.100059Highlights: -o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.15 % in leave-on cosmetic products; - Sodium o-Phenylphenate is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - Sodium o-Phenylphenate is safe when used as preservative up to a maximum concentration of 0.15 % in leave-on cosmetic products; - OPP and Sodium o-Phenylphenate, when used together, should not exceed the maximum concentration 0.15 % in leave-on cosmetic products; - OPP and Sodium o-Phenylphenate, when used together, should not exceed the maximum concentration 0.2 % in rinse-off cosmetic products; - Since this safety dossier related to dermally applied products only, the SCCS did not consider oral and inhalation routes; - This assessment did not cover the safety of O-Phenylphenol and Sodium o-Phenylphenate for the environment.engo-Phenylphenol (OPP)Safety AssessmentEnvironmental GenotoxicityCosmetic IngredientsGenotoxicidade AmbientalSCCS Opinion on Biphenyl-2-ol and Sodium 2-biphenylolate used in cosmetic products (CAS/EC No. 90-43-7/201-993-5 and 132-27-4/205-055-6)– SCCS/1669/24journal article10.1016/j.namjnl.2025.1000353050-6204