Manso, H.Krug, T.Sobral, J.Albergaria, I.Gaspar, G.Ferro, J.M.Oliveira, S.A.Vicente, A.M.2011-09-262011-09-262010-03-11BMC Med Genet. 2010 Mar 11;11:401471-2350doi: 10.1186/1471-2350-11-40http://hdl.handle.net/10400.18/233Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.engDoenças Cardio e Cérebro-vascularesjournal article