Vaz, FátimaFeliciano, AméliaSilva, Ana RitaCoelho, CristinaTorres, Vukosava MillicBozanic, VesnaMalhotra, AtulPinto, PaulaBárbara, CristinaPenque, Deborah2016-02-222016-02-222015-09-28http://hdl.handle.net/10400.18/3459This work was approved by the Ethical Committee of INSA.I.P.-Lisboa, Centro Hospitalar Lisboa-Norte., Faculdade de Ciências Médicas da Universidade Nova de Lisboa and Comissão Nacional de Proteção de Dados, Portugal.DIGE images were obtained in ITQB.Obstructive sleep apnea (OSA) is a sleep¬related breathing disorder characterized by recurrent episodes of apnea/and hypopnea during sleep with resultant intermittent hypoxia and sleep fragmentation, leading to cardiometabolic diseases. OSA affects 3.7% to 26% of adult population, but frequently is underdiagnosed. By 2DIGE-proteomics approach, we have investigated red blood cells (RBC) in OSA to uncover new insights into putative chronic stress-induced RBC dysfunction that lead to inflammation and metabolic syndrome associated with OSA. A number of proteins as potential candidate biomarkers for OSA, such as the cytosolic antioxidant regulators, catalase (CAT) and peroxiredoxin2 (PRX2) was identified, needing additional biochemical research validation.engAntioxidant ActivityRed Blood CelolProteomicsObstructive Aleep ApneiaBiomarkersCardiometabolic DisordersDoenças GenéticasApneia Obstrutiva do Sonoconference object