Michou, L.Cornélis, F.Baron, M.Bombardieri, S.Balsa, A.Westhovens, R.Barrera, P.Alves, H.Radstake, T.R.Migliorini, P.Bardin, T.Petit-Teixeira, E.Boilard, E.2014-10-302014-10-302013-05-28Clin Exp Rheumatol. 2013 Sep-Oct;31(5):770-2. Epub 2013 May 28.0392-856Xhttp://hdl.handle.net/10400.18/2409H. Alves - INSA/Departamento Promoção da Saúde e Prevenção de Doenças Não Transmissíveis (Porto)Beyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheumatoid arthritis (RA) and are thought to amplify inflammation. The gene coding for GPVI is localised on chromosome 19q13.4 and contains different single nucleotide polymorphisms (SNPs). Five non-synonymous SNPs define the major and minor haplotypes of GPVI. The minor haplotype is associated with higher risk of cardiovascular incidents. In this study, we examined whether this minor haplotype is also associated with RA.engPlateletsGlycoprotein VIRheumatoid ArthritisSingle NucleotidePolymorphismHaplotypejournal article