Liu, X.Q.Paterson, A.D.Szatmari, P.Autism Genome Project Consortium2011-11-302011-11-302008-10-01Biol Psychiatry. 2008 Oct 1;64(7):561-70. Epub 2008 Jul 16.0006-3223doi:10.1016/j.biopsych.2008.05.023http://hdl.handle.net/10400.18/332Member of the Autism Genome Project Consortium: Astrid Moura VicenteThe search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of autism since they may be more directly related to the underlying susceptibility loci. Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity.engAutismGenetic heterogeneityIQLanguageLinkage analysisSchizophreniaPerturbações do Desenvolvimento Infantil e Saúde Mentaljournal article