Campos, JoanaMourão, JoanaMarçal, SaraMachado, JorgeNovais, CarlaPeixe, LuísaAntunes, Patrícia2017-03-072017-03-072016-03J Antimicrob Chemother. 2016 Mar;71(3):843-5. doi: 10.1093/jac/dkv409. Epub 2015 Dec 170305-7453http://hdl.handle.net/10400.18/4554Fluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.engAnti-Bacterial AgentsChild, PreschoolElectrophoresis, Gel, Pulsed-FieldEuropeFecesGene OrderGenotypeHumansInfantMetalsMicrobial Sensitivity TestsMolecular TypingPlasmidsSalmonella InfectionsSalmonella typhimuriumSequence Analysis, DNADrug Resistance, BacterialGenes, BacterialInfecções Gastrointestinaisjournal article10.1093/jac/dkv409