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Título: Metals, immune system and disease
Autor: Costa, Luciana
Palavras-chave: Determinantes Imunológicos em Doenças Crónicas
Issue Date: 19-Jan-2011
Editora: Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
Resumo: Ceruloplasmin (CP) is an abundant copper (Cu)-containing plasma glycoprotein that participates in the acute phase reaction to stress. Despite its physiologic role(s) remains unknown, CP antioxidant activity by promoting iron mobilization or scavenging free radicals and thus preventing metal-catalyzed free-radical tissue damage has been widely described. In this presentation, we show human peripheral blood lymphocytes (huPBL) express two distinct CP transcripts: a secreted and a membrane GPI-anchored form. Particularly, we suggest that expression of CP in immune cells could represent an integral part of host response to immunological stress and could contribute to the increase of plasma CP levels observed during acute-phase conditions. Also, we show that the CP protein is localized at huPBL surface and its expression is highly specific to the NK cell lymphocyte subset, suggesting an important role for huPBL-associated CP in the relationship between innate immunity and oxidative biology. As a ferroxidase, CP converts the reduced ferrous iron to oxidized ferric non-toxic form facilitating the movement of iron from cells to the blood. There is also increasing experimental evidence that CP can also function as an extracellular protective enzyme against oxidative stress. In this context, the physiologic relevance of CP expressed by immune cells in iron homeostasis, particularly in oxyradical overload pathologic conditions, is discussed. The functional link between copper/iron metabolism and immunity in specific pathologies related to cardiovascular, neurologic and inflammatory conditions will be presented.
Descrição: Palestra por convite no âmbito do Mestrado em Biologia Humana e Ambiente na Faculdade de Ciências da Universidade de Lisboa, Portugal
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