Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/732
Título: The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
Autor: Haddy, N.
De Bacquer, D.
Chemaly, M.M.
Maurice, M.
Ehnholm, C.
Evans, A.
Sans, S.
Martins, M. do Carmo
De Backer, G.
Siest, G.
Visvikis, S.
Palavras-chave: Cardiovascular Risk
ApoE Polymorphism
ApoE Concentration
Inter-individual Lipid Levels Variation
Doenças Cardio e Cérebro-vasculares
Data: Dez-2002
Editora: Nature Publishing Group
Citação: Eur J Hum Genet. 2002 Dec;10(12):841-50
Resumo: Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the epsilon2 allele frequency and the apoE concentration showed a north-south increasing gradient while the epsilon4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.
Descrição: The ApoEurope group, collaborating centres, and their associated investigators: Portugal: Unidade de Química Clínica, Instituto Nacional de Saúde, Lisboa: Maria do Carmo Martins, Maria Odete Rodrigues, Maria Isabel Albergaria, Maria Liseta Alpendre
URI: http://hdl.handle.net/10400.18/732
ISSN: 1018-4813
Versão do Editor: http://www.nature.com/ejhg/journal/v10/n12/full/5200864a.html
Aparece nas colecções:DPSPDNT - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
The importance of plasma apolipoprotein.pdf205,36 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.