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|Título: ||Dominant and recessive RYR1 mutations in adults with core lesions and mild muscle symptoms|
|Autor: ||Duarte, Sofia|
Central Core Disease
|Issue Date: ||Jul-2011|
|Citação: ||Muscle Nerve. 2011 Jul;44(1):102-8|
|Resumo: ||INTRODUCTION: Ryanodine receptor gene (RYR1) mutations have been associated with central core disease (CCD), multiminicore/minicore/multicore disease (MmD), and susceptibility to malignant hyperthermia (MH).
METHODS: Patients with muscle symptoms in adulthood, who had features compatible with CCD/MmD, underwent clinical, histological, and genetic (RYR1 and SEPN1 genes) evaluations. Published cases of CCD and MmD with adult onset were also reviewed.
RESULTS: Eight patients fulfilled the criteria for further analysis. Five RYR1 mutations, 4 of them unreported, were detected in 3 patients. Compound heterozygosity was proven in 1 case.
CONCLUSIONS: To our knowledge, this is the only report of adult onset associated with recessive RYR1 mutations and central core/multiminicores on muscle biopsy. Although adult patients with CCD, MmD, and minimally symptomatic MH with abnormal muscle biopsy findings usually have a mild clinical course, differential diagnosis and carrier screening is crucial for prevention of potentially life-threatening reactions to general anesthesia.|
|Arbitragem científica: ||yes|
|Versão do Editor: ||http://onlinelibrary.wiley.com/doi/10.1002/mus.22009/abstract|
|Appears in Collections:||DGH - Artigos em revistas internacionais|
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