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Title: I-Move towards monitoring seasonal and pandemic influenza vaccine effectiveness: lessons learnt from a pilot multi-centric case-control study in europe, 2008-9
Authors: Kissling, E.
Valenciano, M.
Falcao, J.
Larrauri, A.
Widgren, K.
Pitigoi, D.
Oroszi, B.
Nunes, Baltazar
Savulescu, C.
Mazick, A.
Lupulescu, E.
Ciancio, B.
Moren, A.
Keywords: Estados de Saúde e de Doença
Seasonal Vaccine
Pandemic Influenza Vaccine
Issue Date: Nov-2009
Publisher: European Centre for Disease Prevention and Control
Citation: Euro Surveill. 2009 Nov 5;14(44). pii: 19388
Abstract: Within I-MOVE (European programme to monitor seasonal and pandemic influenza vaccine effectiveness (IVE)) five countries conducted IVE pilot case-control studies in 2008-9. One hundred and sixty sentinel general practitioners (GP) swabbed all elderly consulting for influenza-like illness (ILI). Influenza confirmed cases were compared to influenza negative controls. We conducted a pooled analysis to obtain a summary IVE in the age group of >or=65 years. We measured IVE in each study and assessed heterogeneity between studies qualitatively and using the I2 index. We used a one-stage pooled model with study as a fixed effect. We adjusted estimates for age-group, sex, chronic diseases, smoking, functional status, previous influenza vaccinations and previous hospitalisations. The pooled analysis included 138 cases and 189 test-negative controls. There was no statistical heterogeneity (I2=0) between studies but ILI case definition, previous hospitalisations and functional status were slightly different. The adjusted IVE was 59.1% (95% CI: 15.3-80.3%). IVE was 65.4% (95% CI: 15.6-85.8%) in the 65-74, 59.6% (95% CI: -72.6 -90.6%) in the age group of >or=75 and 56.4% (95% CI: -0.2-81.3%) for A(H3). Pooled analysis is feasible among European studies. The variables definitions need further standardisation. Larger sample sizes are needed to achieve greater precision for subgroup analysis. For 2009-10, I-MOVE will extend the study to obtain early IVE estimates in groups targeted for pandemic H1N1 influenza vaccination.
Peer review: yes
ISSN: 1560-7917
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Appears in Collections:DEP - Artigos em revistas internacionais

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