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http://hdl.handle.net/10400.18/6842| Title: | Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1b |
| Author: | Gonçalves, Vânia Matos, Paulo Matos Pereira, Joana Henriques, Andreia Jordan, Peter |
| Keywords: | Signalling Pathways Alternative Splicing RAC1b Splicing Alternativo Vias de Transdução de Sinal e Patologias Associadas Cancro Coloretal |
| Issue Date: | 19-Oct-2019 |
| Abstract: | Introduction: In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells. |
| URI: | http://hdl.handle.net/10400.18/6842 |
| Appears in Collections: | DGH - Posters/abstracts em congressos nacionais |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related.pdf | 220,02 kB | Adobe PDF | View/Open Request a copy |
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