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Publicação
A new twist to ibuprofen: alternative action in alternative splicing
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Orientador(es)
Resumo(s)
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One
indication of NSAID use is long-term chemoprevention to decrease the risk of developing various
types of cancer, in particular colorectal cancer. The molecular mechanism behind the antitumour
properties of NSAID has been largely attributed to inhibition of the enzyme cyclooxygenase. In this
review article, the authors highlight that additional mechanisms of NSAID, especially ibuprofen,
action exist that are related to cell signalling and the modulation of gene expression, including
alternative splicing. For example, the authors describe how ibuprofen inhibits expression of the
tumour-related splicing variant RAC1b, which is overexpressed in a specific subset of colorectal
tumours. The mechanism involves changes in the phosphorylation of splicing factors that regulate this
alternative splicing event. According to recent studies, ibuprofen interferes with signal transmission
via protein kinases, a process which is frequently altered in cancer cells.
Descrição
Palavras-chave
ibuprofen Colorectal Cancer Alternative Splicing RAC1b SRPK Vias de Transdução de Sinal e Patologias Associadas
Contexto Educativo
Citação
Eur Med J. 2019;4(2):64-71. Epub 2019 Jun 13
Editora
European Medical Group (EMG)