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http://hdl.handle.net/10400.18/637
Título: | Molecular features underlying the higher ecological success of C. trachomatis E and F genotypes |
Autor: | Nunes, A. Ferreira, R. Borges, V. Borrego, M.J. Gomes, João Paulo |
Palavras-chave: | Infecções Sexualmente Transmissíveis Chlamydia Trachomatis Ecological Sucess |
Data: | Mar-2011 |
Editora: | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP |
Resumo: | In the light of the >98% genomic similarity among Chlamydia trachomatis serovars, the higher worldwide ecological success of E and F is enigmatic. We intend to provide a quick overview of the molecular data that distinguish these from the remaining strains. Examples are: - E and F possess a similar chromosomal genetic make-up distinct from the remaining genotypes. Some loci linked to this independent co-segregation comprehend membrane proteins, hypothetical virulence factors, and regulatory regions (published data). - Some loci reveal nonrandom mutational patterns, where mutations exclusive of E and F are clustered in specific protein domains, likely promoting strains functional and/or structural attributes (published data). - Based on data from a worldwide survey, MOMP of E and F exhibit the lowest mutation rate (22.3-fold lower), implying more fitted antigenic profiles to deal with host immunity (published data). - The likelihood of E and F strains to undergo genetic recombination is about 12-fold lower than that of the other genotypes (P<10-2), suggesting a putative clonal evolution, where superimposed favorable clones may be strongly maintained in vivo (preliminary data from our lab). - Strains E and F do not seem to originate higher infectious load in vivo, when compared with other genital genotypes (published data). Full-genomic data from multiple and diverse clinical isolates will be essential to decipher the secret behind the higher ecological success of E and F strains. |
URI: | http://hdl.handle.net/10400.18/637 |
Aparece nas colecções: | DDI - Posters/abstracts em congressos internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Poster Ecological Success.pdf | 425,28 kB | Adobe PDF | Ver/Abrir |
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