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Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/632

Título: EzrA contributes to the regulation of cell size in Staphylococcus aureus
Autor: Jorge, A.M.
Hoiczyk, E.
Gomes, J.P.
Pinho, M.G.
Palavras-chave: Infecções Respiratórias
Staphylococcus Aureus
Issue Date: 2011
Editora: Public Library of Science
Citação: PLoS One. 2011;6(11):e27542. Epub 2011 Nov 14
Resumo: EzrA is a negative regulator of FtsZ in Bacillus subtilis, involved in the coordination between cell growth and cell division and in the control of the cell elongation-division cycle. We have now studied the role of the Staphylococcus aureus homologue of the B. subtilis EzrA protein and shown that it is not essential for cell viability. EzrA conditional and null mutants have an overall increase of the average cell size, compared to wild type strains. In the larger ezrA mutant S. aureus cells, cell division protein FtsZ and the cell wall synthesizing Penicillin Binding Proteins (PBPs) are not properly localized. This suggests that there may be a maximum cell diameter that allows formation of a Z-ring capable of recruiting the other components of the divisome and of driving cytokinesis. We propose that the major role of EzrA in S. aureus is in cell size homeostasis.
Arbitragem científica: yes
URI: http://hdl.handle.net/10400.18/632
ISSN: 1932-6203
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027542
Appears in Collections:DDI - Artigos em revistas internacionais

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