Colorectal Cancer Subtypes – The Current Portrait

Jordan, Peter

doi:10.1007/978-3-030-02771-1_1

Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.18/5792

Title:	Colorectal Cancer Subtypes – The Current Portrait
Author:	Jordan, Peter
Keywords:	Colorectal Cancer Chromosomal Instability Colorectal Cancer Subtype Consensus Molecular Subtype Microsatellite Instability Oncogene Polyp Serrated Pathway Vias de Transdução de Sinal e Patologias Associadas
Issue Date:	Dec-2018
Publisher:	Springer International Publishing
Citation:	In: Jordan P. (ed). Targeted Therapy of Colorectal Cancer Subtypes. Springer, Cham, 2018, pp. 1-6. (Advances in Experimental Medicine and Biology; vol. 1110). Doi: 10.1007/978-3-030-02771-1_1
Series/Report no.:	Advances in Experimental Medicine and Biology;volume 1110
Abstract:	Colorectal cancer (CRC) is one prominent example for how chemotherapy has been changing by moving from the use of general cytotoxic agents to more tumour-specific drugs. For example, antibody-based drugs neutralize a growth factor receptor protein on the surface of tumour cells. The development of such new therapeutic opportunities requires a more thorough and systematic subclassification of CRC because tumour cells can exploit several alternative genetic pathways for their survival. This chapter gives an overview on CRC subtypes as an introduction to the following book chapters that will describe aspects of specific subtypes, and how these may lead to the development of novel pathway-specific drugs for a more precise therapeutic intervention.
URI:	http://hdl.handle.net/10400.18/5792
DOI:	10.1007/978-3-030-02771-1_1
Publisher Version:	https://link.springer.com/chapter/10.1007%2F978-3-030-02771-1_1
Appears in Collections:	DGH - Capítulos (ou partes) de livros

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