Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/565
Título: Paper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe
Autor: Loane, Maria
Dolk, Helen
Kelly, Alan
Teljeur, Conor
Greenlees, Ruth
Densem, James
EUROCAT Working Group
Palavras-chave: Congenital Anomalies
Estados de Saúde e de Doença
Data: 4-Mar-2011
Editora: Wiley-Liss
Citação: Birth Defects Res A Clin Mol Teratol. 2011 Mar;91 Suppl 1:S31-43. Epub 2011 Mar 4
Resumo: As part of EUROCAT’s surveillance of congenital anomalies in Europe, a statistical monitoring system has been developed to detect recent clusters or long-term (10 year) time trends. The purpose of this article is to describe the system for the identification and investigation of 10-year time trends, conceived as a ‘‘screening’’ tool ultimately leading to the identification of trends which may be due to changing teratogenic factors. METHODS: The EUROCAT database consists of all cases of congenital anomalies including livebirths, fetal deaths from 20 weeks gestational age, and terminations of pregnancy for fetal anomaly. Monitoring of 10-year trends is performed for each registry for each of 96 non-independent EUROCAT congenital anomaly subgroups, while Pan-Europe analysis combines data from all registries. The monitoring results are reviewed, prioritized according to a prioritization strategy, and communicated to registries for investigation. Twenty-one registries covering over 4 million births, from 1999 to 2008, were included in monitoring in 2010. CONCLUSIONS: Significant increasing trends were detected for abdominal wall anomalies, gastroschisis, hypospadias, Trisomy 18 and renal dysplasia in the Pan-Europe analysis while 68 increasing trends were identified in individual registries. A decreasing trend was detected in over one-third of anomaly subgroups in the Pan-Europe analysis, and 16.9% of individual registry tests. Registry preliminary investigations indicated that many trends are due to changes in data quality, ascertainment, screening, or diagnostic methods. Some trends are inevitably chance phenomena related to multiple testing, while others seem to represent real and continuing change needing further investigation and response by regional/national public health authorities.
Descrição: EUROCAT Working group collaborator: Carlos Dias
Peer review: yes
URI: http://hdl.handle.net/10400.18/565
ISSN: 1542-0752
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/bdra.20778/abstract;jsessionid=7381672AC9545033A37EEC47A3CA886C.d01t03
Aparece nas colecções:DEP - Artigos em revistas internacionais

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