Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5596
Título: Analysis of shared heritability in common disorders of the brain
Autor: Anttila, Verneri
Bulik-Sullivan, Brendan
Finucane, Hilary K.
Walters, Raymond K.
Bras, Jose
Duncan, Laramie
Escott-Price, Valentina
Falcone, Guido J.
Gormley, Padhraig
Malik, Rainer
Patsopoulos, Nikolaos A.
Schoch, Susanne
Sisodiya, Sanjay M.
Smith, Philip
Sperling, Michael
Striano, Pasquale
Surges, Rainer
Thomas, G. Neil
Visscher, Frank
Whelan, Christopher D.
Berr, Claudine
Kurth, Tobias
Zara, Federico
Heinzen, Erin L.
Marson, Anthony
Becker, Felicitas
Stroink, Hans
Zimprich, Fritz
Gasser, Thomas
Gibbs, Raphael
Heutink, Peter
Martinez, Maria
Ligthart, Lannie
Letenneur, Luc
Morris, Huw R.
Sharma, Manu
Ryten, Mina
Mok, Kin Y.
Pulit, Sara
Bevan, Steve
Holliday, Elizabeth
Attia, John
Battey, Thomas
Terwindt, Gisela M.
Boncoraglio, Giorgio
Hannequin, Didier
Thijs, Vincent
Chen, Wei-Min
Mitchell, Braxton
Rothwell, Peter
Sharma, Pankaj
Sudlow, Cathie
Vicente, Astrid
Markus, Hugh
Freilinger, Tobias
Kourkoulis, Christina
Pera, Joana
Amouyel, Philippe
Raffeld, Miriam
Silliman, Scott
Boraska Perica, Vesna
Thornton, Laura M.
Huckins, Laura M.
William Rayner, N.
Lewis, Cathryn M.
Ran, Caroline
Gratacos, Monica
Rybakowski, Filip
Keski-Rahkonen, Anna
Boland, Anne
Raevuori, Anu
Hudson, James I.
Reichborn-Kjennerud, Ted
Monteleone, Palmiero
Karwautz, Andreas
Mannik, Katrin
Gordon, Scott D.
Baker, Jessica H.
O’Toole, Julie K.
Trace, Sara E.
Davis, Oliver S. P.
Deleuze, Jean-François
Helder, Sietske G.
Ehrlich, Stefan
Herpertz-Dahlmann, Beate
Danner, Unna N.
van Elburg, Annemarie A.
Borck, Guntram
Clementi, Maurizio
Forzan, Monica
Docampo, Elisa
Lissowska, Jolanta
Hauser, Joanna
Duron, Emmanuelle
Tortorella, Alfonso
Maj, Mario
Gonidakis, Fragiskos
Tziouvas, Konstantinos
Adams, Hieab H.H.
Papezova, Hana
Yilmaz, Zeynep
Wagner, Gudrun
Cohen-Woods, Sarah
Herms, Stefan
Julià, Antonio
Vardarajan, Badri N.
Rabionet, Raquel
Dick, Danielle M.
Ripatti, Samuli
Lehtimäki, Terho
Andreassen, Ole A.
Espeseth, Thomas
Lundervold, Astri J.
Steen, Vidar M.
Pinto, Dalila
Scherer, Stephen W.
Aschauer, Harald
Reitz, Christiane
Schosser, Alexandra
Alfredsson, Lars
Wedenoja, Juho
Padyukov, Leonid
Halmi, Katherine A.
Mitchell, James
Strober, Michael
Bergen, Andrew W.
Kaye, Walter
Szatkiewicz, Jin Peng
Cormand, Bru
Goate, Alison M.
Ramos-Quiroga, Josep Antoni
Ripke, Stephan
Sánchez-Mora, Cristina
Ribasés, Marta
Casas, Miguel
Hervas, Amaia
Arranz, Maria Jesús
Haavik, Jan
Zayats, Tetyana
Johansson, Stefan
Williams, Nigel
Huentelman, Matthew J.
Buring, Julie E.
Elia, Josephine
Dempfle, Astrid
Rothenberger, Aribert
Kuntsi, Jonna
Oades, Robert D.
Banaschewski, Tobias
Franke, Barbara
Buitelaar, Jan K.
Arias Vasquez, Alejandro
Doyle, Alysa E.
Schürks, Markus
Kamboh, M. Ilyas
Reif, Andreas
Lesch, Klaus-Peter
Freitag, Christine
Rivero, Olga
Palmason, Haukur
Romanos, Marcel
Langley, Kate
Rietschel, Marcella
Witt, Stephanie H.
Hrafnsdottir, Maria
Dalsgaard, Soeren
Larson, Eric B.
Børglum, Anders D.
Waldman, Irwin
Wilmot, Beth
Molly, Nikolas
Bau, Claiton H.D.
Crosbie, Jennifer
Schachar, Russell
Loo, Sandra K.
Hottenga, Jouke-Jan
McGough, James J.
Grevet, Eugenio H.
Rogaeva, Ekaterina
Medland, Sarah E.
Robinson, Elise
Weiss, Lauren A.
Bacchelli, Elena
Bailey, Anthony
Bal, Vanessa
Battaglia, Agatino
Penninx, Brenda
Betancur, Catalina
Bolton, Patrick
Cantor, Rita
St George-Hyslop, Peter
Celestino-Soper, Patrícia
Dawson, Geraldine
De Rubeis, Silvia
Duque, Frederico
Green, Andrew
Klauck, Sabine M.
Artto, Ville
Leboyer, Marion
Levitt, Pat
Maestrini, Elena
Mane, Shrikant
Hakonarson, Hakon
De-Luca, Daniel Moreno-
Parr, Jeremy
Regan, Regina
Reichenberg, Abraham
Sandin, Sven
Kaunisto, Mari
Vorstman, Jacob
Wassink, Thomas
Wijsman, Ellen
Cook, Edwin
Santangelo, Susan
Kukull, Walter A.
Delorme, Richard
Rogé, Bernadette
Magalhaes, Tiago
Arking, Dan
Vepsäläinen, Salli
Schulze, Thomas G.
Thompson, Robert C.
Strohmaier, Jana
Matthews, Keith
Melle, Ingrid
Morris, Derek
Farrer, Lindsay A.
Blackwood, Douglas
McIntosh, Andrew
Bergen, Sarah E
Martin, Nicholas G.
Schalling, Martin
Jamain, Stéphane
Maaser, Anna
Fischer, Sascha B.
Reinbold, Céline S.
Fullerton, Janice M.
Grigoroiu-Serbanescu, Maria
Barnes, Lisa L.
Guzman-Parra, José
Mayoral, Fermin
Montgomery, Grant W.
Schofield, Peter R.
Cichon, Sven
Mühleisen, Thomas W.
Degenhardt, Franziska
Schumacher, Johannes
Bauer, Michael
Mitchell, Philip B.
Gershon, Elliot S.
Beach, Thomas G.
Rice, John
Wei, Zhi
Potash, James B.
Zandi, Peter P.
Craddock, Nick
Ferrier, I. Nicol
Alda, Martin
Rouleau, Guy A.
Turecki, Gustavo
Ophoff, Roel
Pato, Carlos
Demirci, F. Yesim
Kurki, Mitja I.
Anjorin, Adebayo
Stahl, Eli
Leber, Markus
Czerski, Piotr M.
Edenberg, Howard J.
Cruceanu, Cristiana
Jones, Ian R.
Posthuma, Danielle
Andlauer, Till F.M.
Forstner, Andreas J.
Hämäläinen, Eija
Head, Elizabeth
Streit, Fabian
Baune, Bernhard T.
Air, Tracy
Sinnamon, Grant
Wray, Naomi R.
MacIntyre, Donald J.
Porteous, David
Homuth, Georg
Rivera, Margarita
Huang, Hailiang
Grove, Jakob
Hulette, Christine M.
Middeldorp, Christel M.
Hickie, Ian
Pergadia, Michele
Mehta, Divya
Smit, Johannes H.
Jansen, Rick
de Geus, Eco
Dunn, Erin
Huang, Jie
Li, Qingqin S.
Nauck, Matthias
Jicha, Gregory A.
Schoevers, Robert A.
Beekman, Aartjan TF
Knowles, James A.
Viktorin, Alexander
Arnold, Paul
Barr, Cathy L.
Bedoya-Berrio, Gabriel
Sandor, Cynthia
Bienvenu, O. Joseph
Brentani, Helena
Burton, Christie
Kauwe, John S.K.
Camarena, Beatriz
Cappi, Carolina
Cath, Danielle
Cavallini, Maria
Cusi, Daniele
Darrow, Sabrina
Webber, Caleb
Denys, Damiaan
Derks, Eske M.
Dietrich, Andrea
Fernandez, Thomas
Kaye, Jeffrey A.
Figee, Martijn
Freimer, Nelson
Gerber, Gloria
Grados, Marco
Greenberg, Erica
Muller-Myhsok, Bertram
Hanna, Gregory L.
Hartmann, Andreas
Hirschtritt, Matthew E.
Hoekstra, Pieter J.
Huang, Alden
Leverenz, James B.
Huyser, Chaim
Illmann, Cornelia
Jenike, Michael
Kuperman, Samuel
Schreiber, Stefan
Leventhal, Bennett
Lochner, Christine
Lyon, Gholson J.
Macciardi, Fabio
Madruga-Garrido, Marcos
Malaty, Irene A.
Levey, Allan I.
Maras, Athanasios
McGrath, Lauren
Miguel, Eurípedes C.
Salomaa, Veikko
Mir, Pablo
Nestadt, Gerald
Nicolini, Humberto
Okun, Michael S.
Pakstis, Andrew
Paschou, Peristera
Piacentini, John
Lieberman, Andrew P.
Pittenger, Christopher
Plessen, Kerstin
Loehrer, Elizabeth
Ramensky, Vasily
Ramos, Eliana M.
Reus, Victor
Richter, Margaret A.
Riddle, Mark A.
Robertson, Mary M.
Roessner, Veit
Rosário, Maria
Pankratz, Vernon S.
Samuels, Jack F.
Yu, Dongmei
Sandor, Paul
Stein, Dan J.
Tsetsos, Fotis
Van Nieuwerburgh, Filip
Weatherall, Sarah
Wendland, Jens R.
Wolanczyk, Tomasz
Worbe, Yulia
Zai, Gwyneth
Poon, Wayne W.
Göbel, Hartmut
Goes, Fernando S.
McLaughlin, Nicole
Nestadt, Paul S.
Grabe, Hans-Jorgen
Depienne, Christel
Konkashbaev, Anuar
Lanzagorta, Nuria
Valencia-Duarte, Ana
Bramon, Elvira
Buccola, Nancy
Macaya, Alfons
Quinn, Joseph F.
Cahn, Wiepke
Cairns, Murray
Chong, Siow A.
Cohen, David
Crespo-Facorro, Benedicto
Crowley, James
Davidson, Michael
DeLisi, Lynn
Dinan, Timothy
Pozo-Rosich, Patricia
Donohoe, Gary
Saykin, Andrew J.
Drapeau, Elodie
Duan, Jubao
Haan, Lieuwe
Hougaard, David
Karachanak-Yankova, Sena
Khrunin, Andrey
Klovins, Janis
Kučinskas, Vaidutis
Hansen, Thomas
Lee Chee Keong, Jimmy
Limborska, Svetlana
Schneider, Lon S.
Loughland, Carmel
Lönnqvist, Jouko
Maher, Brion
Mattheisen, Manuel
McDonald, Colm
Murphy, Kieran C.
Murray, Robin
Werge, Thomas
Nenadic, Igor
van Os, Jim
Pantelis, Christos
Smith, Amanda G.
Pato, Michele
Petryshen, Tracey
Quested, Digby
Roussos, Panos
Sanders, Alan R.
Schall, Ulrich
Kaprio, Jaakko
Schwab, Sibylle G.
Sim, Kang
So, Hon-Cheong
Stögmann, Elisabeth
Sonnen, Joshua A.
Subramaniam, Mythily
Toncheva, Draga
Waddington, John
Walters, James
Weiser, Mark
Metspalu, Andres
Cheng, Wei
Cloninger, Robert
Curtis, David
Gejman, Pablo V.
Henskens, Frans
Stern, Robert A.
Mattingsdal, Morten
Oh, Sang-Yun
Scott, Rodney
Webb, Bradley
Kubisch, Christian
Breen, Gerome
Churchhouse, Claire
Bulik, Cynthia M.
Daly, Mark
Dichgans, Martin
Faraone, Stephen V.
Van Deerlin, Vivianna M.
Guerreiro, Rita
Holmans, Peter
Kendler, Kenneth S.
Ferrari, Michel D.
Koeleman, Bobby
Mathews, Carol A.
Price, Alkes
Scharf, Jeremiah
Sklar, Pamela
Williams, Julie
Wood, Nicholas W.
Van Eldik, Linda J.
Cotsapas, Chris
Palotie, Aarno
Belin, Andrea C.
Smoller, Jordan W.
Sullivan, Patrick
Rosand, Jonathan
Corvin, Aiden
Neale, Benjamin M.
The Brainstorm Consortium
Harold, Denise
Russo, Giancarlo
Rubinsztein, David C.
Bayer, Anthony
Lee, Phil H.
Tsolaki, Magda
Proitsi, Petra
Fox, Nick C.
Hampel, Harald
Owen, Michael J.
Mead, Simon
Passmore, Peter
Morgan, Kevin
Nöthen, Markus M.
Schott, Jonathan M.
van den Maagdenberg, Arn M.J.M.
Rossor, Martin
Lupton, Michelle K.
Hoffmann, Per
Kornhuber, Johannes
Lawlor, Brian
McQuillin, Andrew
Al-Chalabi, Ammar
Bis, Joshua C
Ruiz, Agustin
Boada, Mercè
Zwart, John-Anker
Seshadri, Sudha
Beiser, Alexa
Rice, Kenneth
van der Lee, Sven J.
De Jager, Philip L.
Geschwind, Daniel H.
Riemenschneider, Matthias
Riedel-Heller, Steffi
Rotter, Jerome I
Ransmayr, Gerhard
Boomsma, Dorret
Hyman, Bradley T.
Cruchaga, Carlos
Alegret, Montserrat
Winsvold, Bendik
Palta, Priit
Farh, Kai-How
Cuenca-Leon, Ester
Furlotte, Nicholas
Eriksson, Nicholas
Olesen, Jes
Chasman, Daniel I.
Nyholt, Dale R.
Anney, Richard
Avbersek, Andreja
Baum, Larry
Turley, Patrick
Berkovic, Samuel
Bradfield, Jonathan
Buono, Russell
Catarino, Claudia B.
Cossette, Patrick
De Jonghe, Peter
Depondt, Chantal
Dlugos, Dennis
Ferraro, Thomas N.
French, Jacqueline
Grenier-Boley, Benjamin
Hjalgrim, Helle
Jamnadas-Khoda, Jennifer
Kälviäinen, Reetta
Kunz, Wolfram S.
Lerche, Holger
Leu, Costin
Lindhout, Dick
Lo, Warren
Lowenstein, Daniel
McCormack, Mark
Chouraki, Vincent
Møller, Rikke S.
Molloy, Anne
Ng, Ping-Wing
Oliver, Karen
Privitera, Michael
Radtke, Rodney
Ruppert, Ann-Kathrin
Sander, Thomas
Schachter, Steven
Schankin, Christoph
Kamatani, Yoichiro
Scheffer, Ingrid
Palavras-chave: Brain
Disorders of the Brain
Psychiatric Genomics
Genetic Factors
Psychiatric Disorders
Neurological Disorders
Risks factors
Etiology
Perturbações do Desenvolvimento Infantil e Saúde Mental
Data: 22-Jan-2018
Editora: American Association for the Advancement of Science
Citação: Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757
Resumo: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Descrição: Astrid Vicente (INSA), member of The Brainstorm Consortium.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5596
DOI: 10.1126/science.aap8757
ISSN: 0036-8075
1095-9203
Versão do Editor: http://science.sciencemag.org/content/360/6395/eaap8757.long
Aparece nas colecções:DPSPDNT - Artigos em revistas internacionais

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