Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5500
Título: Rab GTPases regulate the trafficking of channels and transporters - a focus on cystic fibrosis
Autor: Farinha, Carlos
Matos, Paulo
Palavras-chave: GTPase
Cystic Fibrosis
Membrane Traffic
Vias de Transdução de Sinal e Patologias Associadas
Data: 2-Mai-2017
Editora: Taylor & Francis
Citação: Small GTPases. 2017 May 2:1-9. doi: 10.1080/21541248.2017.1317700. [Epub ahead of print]
Resumo: The amount of ion channels and transporters present at the plasma membrane is a crucial component of the overall regulation of ion transport. The number of channels present result from an intricate network of proteins that controls the late events of channel trafficking, such as endocytosis, recycling and targeting to lysosomal degradation. Small GTPases of the Rab family are key players in these processes thus contributing to regulation of fluid secretion and ion homeostasis. In epithelia, this involves mainly the balance between the chloride channel CFTR and the sodium channel ENaC, whose misfunction is a hallmark of cystic fibrosis - the commonest recessive disorder in Caucasians. Here, we review the role of GTPases in regulating trafficking of ion channels and transporters, comparing what is known for CFTR and ENaC with other types of channels. We also discuss how feasible would be to target the Rab machinery to handle a disorder such as CF.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5500
DOI: 10.1080/21541248.2017.1317700
ISSN: 2154-1248
Versão do Editor: https://www.tandfonline.com/doi/full/10.1080/21541248.2017.1317700
Aparece nas colecções:DGH - Artigos em revistas internacionais

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