Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5476
Título: Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort
Autor: Marinho, António
Carvalho, Cláudia
Boleixa, Daniela
Bettencourt, Andreia
Leal, Bárbara
Guimarães, Judite
Neves, Esmeralda
Oliveira, José Carlos
Almeida, Isabel
Farinha, Fátima
Costa, Paulo P.
Vasconcelos, Carlos
Silva, Berta M.
Palavras-chave: Adult
Antibodies, Antinuclear
CD4-Positive T-Lymphocytes
Calcium
Complement C3
Female
Forkhead Transcription Factors
Humans
Interleukin-17
Lupus Erythematosus, Systemic
Male
Middle Aged
Phosphorus
Portugal
Vitamin D
Dietary Supplements
Doenças Genéticas
Data: Fev-2017
Editora: Humana Press
Citação: Immunol Res. 2017 Feb;65(1):197-206. doi: 10.1007/s12026-016-8829-3
Resumo: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi-organ inflammation, linked to loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies, with a negative impact on the patients' quality of life. Regulatory T cells have been reported as deficient in number and function in SLE patients. However, some authors also described an enrichment of this cell type. The hypothesis that certain forms of autoimmunity may result from a conversion of Treg cells into a Th17 cell phenotype has been suggested by some studies. In fact, in SLE patients' sera, the IL-17 levels were observed as abnormally high when compared with healthy individuals. Environmental factors, such as vitamin D, that is considered a potential anti-inflammatory agent, combined with genetic and hormonal characteristics have been associated with SLE phenotype and with disease progression. The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio. Additionally, disease evolution, serum vitamin D levels, serum autoantibodies levels and calcium metabolism (to assure safety) were also studied. We assessed 24 phenotypically well-characterized SLE patients. All patients were screened before vitamin D supplementation and 3 and 6 months after the beginning of this treatment. Peripheral blood lymphocyte's subsets were analysed by flow cytometry. Serum 25(OH)D levels significantly increased under vitamin D supplementation (p = 0.001). The FoxP3+/IL-17A ratio in SLE patients after 6 months of vitamin D supplementation was higher than that in the baseline (p < 0.001). In conclusion, this study demonstrated that vitamin D supplementation provided favourable, immunological and clinical impact on SLE.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5476
DOI: 10.1007/s12026-016-8829-3
ISSN: 0257-277X
Versão do Editor: https://link.springer.com/article/10.1007%2Fs12026-016-8829-3
Aparece nas colecções:DGH - Artigos em revistas internacionais

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