Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5467
Título: The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population
Autor: Bettencourt, Andreia
Boleixa, Daniela
Guimarães, Ana Luísa
Leal, Bárbara
Carvalho, Cláudia
Brás, Sandra
Samões, Raquel
Santos, Ernestina
Costa, Paulo Pinho
Silva, Berta
da Silva, Ana Martins
Palavras-chave: Adult
Deoxyribonucleases, Type II Site-Specific
Female
Humans
Male
Multiple Sclerosis
Polymorphism, Single Nucleotide
Portugal
Receptors, Calcitriol
Young Adult
Doenças Genéticas
Data: 15-Ago-2017
Editora: Elsevier/International Society for Neuroimmunology
Citação: J Neuroimmunol. 2017 Aug 15;309:34-37. doi: 10.1016/j.jneuroim.2017.05.005. Epub 2017 May 11.
Resumo: The cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. The purpose of this study was to evaluate the influence of FokI VDR polymorphism in MS development and progression.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5467
DOI: 10.1016/j.jneuroim.2017.05.005
ISSN: 0165-5728
Versão do Editor: http://www.jni-journal.com/article/S0165-5728(17)30069-3/fulltext
Aparece nas colecções:DGH - Artigos em revistas internacionais

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