Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5461
Título: Signaling Pathways Driving Aberrant Splicing in Cancer Cells
Autor: Gonçalves, Vânia
Pereira, Joana F.S.
Jordan, Peter
Palavras-chave: Alternative Splicing
Cancer Cell
Genetic Program
Signaling Pathway
Tumor Microenvironment
Tumorigenesis
Vias de Transdução de Sinal e Patologias Associadas
Data: 29-Dez-2017
Editora: MDPI
Citação: Genes (Basel). 2017 Dec 29;9(1). pii: E9. doi: 10.3390/genes9010009.
Resumo: Aberrant profiles of pre-mRNA splicing are frequently observed in cancer. At the molecular level, an altered profile results from a complex interplay between chromatin modifications, the transcriptional elongation rate of RNA polymerase, and effective binding of the spliceosome to the generated transcripts. Key players in this interplay are regulatory splicing factors (SFs) that bind to gene-specific splice-regulatory sequence elements. Although mutations in genes of some SFs were described, a major driver of aberrant splicing profiles is oncogenic signal transduction pathways. Signaling can affect either the transcriptional expression levels of SFs or the post-translational modification of SF proteins, and both modulate the ratio of nuclear versus cytoplasmic SFs in a given cell. Here, we will review currently known mechanisms by which cancer cell signaling, including the mitogen-activated protein kinases (MAPK), phosphatidylinositol 3 (PI3)-kinase pathway (PI3K) and wingless (Wnt) pathways but also signals from the tumor microenvironment, modulate the activity or subcellular localization of the Ser/Arg rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) families of SFs.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5461
DOI: 10.3390/genes9010009
ISSN: 2073-4425,
Versão do Editor: http://www.mdpi.com/2073-4425/9/1/9
Aparece nas colecções:DGH - Artigos em revistas internacionais

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