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Title: Regulation of glucose transporters by protein kinases in cancer cells
Author: Henriques, Andreia F.
Matos, Paulo
Jordan, Peter
Keywords: WNK Protein Kinases
Colorectal Cancer
Tumor Cells
WNK Proteina Cinases
Transporte de Glucose
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
Issue Date: Oct-2017
Publisher: European Medical Journal
Citation: EMJ Oncol. 2017;5[1]:50-52. Abstract Review No. AR9.
Abstract: Reprogramming of energy metabolism is one of the hallmarks of cancer, since tumour cells need to fuel their high proliferation rates. Warburg et al. first observed that cancer cells largely limit their method of energy production to glycolysis only. In order to compensate for lower ATP yields, cancer cells often upregulate expression of glucose transporters, typically GLUT1, which substantially increases extracellular glucose import into the cytoplasm.
Peer review: no
DOI: 10.1093/annonc/mdx361.036
ISSN: 2054-619X
Publisher Version:
Appears in Collections:DGH - Artigos em revistas internacionais

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