Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5393
Registo completo
Campo DCValorIdioma
dc.contributor.authorHenriques, Andreia-
dc.contributor.authorMatos, Paulo-
dc.contributor.authorJordan, Peter-
dc.date.accessioned2018-03-13T12:49:58Z-
dc.date.available2018-03-13T12:49:58Z-
dc.date.issued2017-09-
dc.identifier.citationAnn Oncol. 2017 Sept;28(Suppl 5):50-52. doi:10.1093/annonc/mdx361.036.-
dc.identifier.issn0923-7534-
dc.identifier.urihttp://hdl.handle.net/10400.18/5393-
dc.descriptionESMO 2017 - 42nd European Society of Medical Oncology Congress 2017, 8-12 September 2017, Madrid, Spain-
dc.description.abstractBackground: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia BioISI - Biosystems and Integrative Sciences Institutept_PT
dc.language.isoengpt_PT
dc.publisherOxford University Press/European Society for Medical Oncology-
dc.rightsopenAccesspt_PT
dc.subjectWNK Protein Kinasespt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectTransporte de Glucosept_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro Coloretalpt_PT
dc.titleRegulation of glucose transporters by protein kinases in cancer cellspt_PT
dc.typeconferenceObjectpt_PT
dc.peerreviewednopt_PT
dc.description.versionN/Apt_PT
degois.publication.titleAnnals of Oncology-
dc.relation.publisherversionhttp://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/Regulation-of-glucose-transporters-by-protein-kinases-in-cancer-cellspt_PT
dc.relation.publisherversionhttps://academic.oup.com/annonc/article/28/suppl_5/mdx361.036/4108277?searchresult=1-
dc.identifier.doi10.1093/annonc/mdx361.036-
Aparece nas colecções:DGH - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
abstract #3699 esmo 2017_AH.pdf210,36 kBAdobe PDFVer/Abrir
Regulation of glucose_mdx361.036.pdf61,67 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.