Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5393
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dc.contributor.authorHenriques, Andreia-
dc.contributor.authorMatos, Paulo-
dc.contributor.authorJordan, Peter-
dc.descriptionAbstract publicado em: Ann Oncol. 2017 Sept;28(Suppl 5):50-52. doi:10.1093/annonc/mdx361.036.-
dc.description.abstractBackground: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia BioISI - Biosystems and Integrative Sciences Institutept_PT
dc.subjectWNK Protein Kinasespt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectTransporte de Glucosept_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro Coloretalpt_PT
dc.titleRegulation of glucose transporters by protein kinases in cancer cellspt_PT
degois.publication.locationMadrid, Spainpt_PT
degois.publication.titleESMO 2017 - 42nd European Society of Medical Oncology Congress 2017, 8-12 September 2017pt_PT
Aparece nas colecções:DGH - Posters/abstracts em congressos internacionais

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