Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5393
Título: Regulation of glucose transporters by protein kinases in cancer cells
Autor: Henriques, Andreia
Matos, Paulo
Jordan, Peter
Palavras-chave: WNK Protein Kinases
Colorectal Cancer
Transporte de Glucose
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
Data: Set-2017
Resumo: Background: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.
Descrição: Abstract publicado em: Ann Oncol. 2017 Sept;28(Suppl 5):50-52. doi:10.1093/annonc/mdx361.036.
Peer review: no
URI: http://hdl.handle.net/10400.18/5393
Versão do Editor: http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/Regulation-of-glucose-transporters-by-protein-kinases-in-cancer-cells
Aparece nas colecções:DGH - Posters/abstracts em congressos internacionais

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abstract #3699 esmo 2017_AH.pdf210,36 kBAdobe PDFVer/Abrir
Regulation of glucose_mdx361.036.pdf61,67 kBAdobe PDFVer/Abrir

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