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Title: Regulation of glucose transporters by protein kinases in cancer cells
Author: Henriques, Andreia
Matos, Paulo
Jordan, Peter
Keywords: WNK Protein Kinases
Colorectal Cancer
Transporte de Glucose
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
Issue Date: Sep-2017
Publisher: Oxford University Press/European Society for Medical Oncology
Citation: Ann Oncol. 2017 Sept;28(Suppl 5):50-52. doi:10.1093/annonc/mdx361.036.
Abstract: Background: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.
Description: ESMO 2017 - 42nd European Society of Medical Oncology Congress 2017, 8-12 September 2017, Madrid, Spain
Peer review: no
DOI: 10.1093/annonc/mdx361.036
ISSN: 0923-7534
Publisher Version:
Appears in Collections:DGH - Artigos em revistas internacionais

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