Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/5175
Título: Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Portugal
Autor: Simões, Maria João
Bettencourt, Célia
De Paola, Rosita
Giuliani, Maria
Pizza, Mariagrazia
Moschioni, Monica
Machado, Jorge
Palavras-chave: Meningococci Group B
Vaccine
Strain Coverage
Neisseria meningitidis
Infecções Respiratórias
Data: 1-Mai-2017
Editora: PlosOne
Citação: PLoS One. 2017 May 1;12(5):e0176177. doi: 10.1371/journal.pone.0176177. eCollection 2017.
Resumo: Objective: Although the incidence of meningococcal disease has been declining over the past decade in Portugal MenB meningococci is still an important cause of meningitis and sepsis. The aim of this study was to estimate the strain coverage of the 4CMenB vaccine in Portugal in order to support health policies for prevention and control of meningococcal disease. Methods: Since 2002 the clinical and laboratory notification of meningococcal disease is mandatory in Portugal. National database includes since then all confirmed cases notified to the reference laboratory or to the Directorate of Health. Strains included in this study were all the invasive MenB isolated from the 1st July 2011 to the 30th June 2015, sent to the reference laboratory. To predict the vaccine strain coverage of the 4CMenB the expression and cross-reactivity of the surface antigens fHbp, NadA, NHBA were assessed by the Meningococcal Antigen Typing System (MATS) whereas PorA typing was performed by sequencing. The presence of at least one antigen with a Relative Potency (RP) greater than its MATS-positive bactericidal threshold RP value or the presence of PorA VR2 = 4 was considered to be predictive for a strain to be covered by the 4CMenB vaccine. Results: The estimated 4CMenB strain coverage in Portugal was 67.9%. The percentage of strain coverage in each of the four epidemiological years ranged from 63.9% to 73.7%. Strains covered by one antigen represent 32.1% of the total of isolates, 29.2% of strains were covered by two antigens and 6.6% by three antigens. No strain had all the four antigens. Antigens that most contributed for coverage were NHBA and fHbp. Data from Portugal is in accordance with the MATS predicted strain coverage in five European countries (England and Wales, France, Germany, Italy and Norway) that pointed to 78% coverage for strains collected in the epidemiological year 2007-2008.
Peer review: yes
URI: http://hdl.handle.net/10400.18/5175
DOI: 10.1371/journal.pone.0176177
ISSN: 1932-6203
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176177
Aparece nas colecções:DDI - Artigos em revistas internacionais

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