Repositório Científico do Instituto Nacional de Saúde >
Departamento de Saúde Ambiental >
DSA - Artigos em revistas internacionais >

Please use this identifier to cite or link to this item:

Título: Occupational Exposure to Formaldehyde: Genotoxic Risk Evaluation By Comet Assay And Micronucleus Test Using Human Peripheral Lymphocytes
Autor: Costa, S.
Pina, C.
Coelho, P.
Costa, C.
Silva, S.
Porto, B.
Laffon, B.
Teixeira, J.P.
Palavras-chave: Formaldehyde
Occupational Exposure
Micronucleus Test
Comet Assay
Ar e Saúde Ocupacional
Issue Date: 27-Jun-2011
Editora: Taylor & Francis
Citação: J Toxicol Environ Health A. 2011 Aug;74(15-16):1040-51
Resumo: Formaldehyde (FA) is a world high-production compound with numerous applications ranging from production of resins to medicines. Due to its sensitizing properties, irritating effects and potential cancer hazard FA is of great environmental health concern. Numerous studies in humans and experimental animals demonstrated that inhaled FA produced toxicity, genotoxicity, and cancer at distal sites. IARC, based on sufficient data, reclassified FA as a human carcinogen. The highest level of human exposure to this aldehyde occurs in occupational settings, namely, in pathology and anatomy laboratories, where FA is commonly used as a fixative and tissue preservative. Several studies consistently showed that the levels of airborne FA in anatomy laboratories exceeded recommended exposure criteria. In order to assess the genotoxic effects of chronic occupational exposure to FA, a group of pathology/anatomy workers was assessed using a micronucleus (MN) test and comet assay. The level of exposure to FA was also determined and the time-weighted average (TWA) of exposure was calculated for each subject. The TWA mean value for FA exposed workers was 0.43 ± 0.06 ppm, exceeding national and international recommended limit levels of 0.3 ppm. Both MN frequency and comet assay parameters were significantly higher in exposed subjects. Data obtained confirm a correlation between genetic damage and occupational exposure to FA. These data, along with recent implications of human carcinogenicity, point out the need for close monitoring of occupational exposure to FA. Implementation of security and hygiene measures as well as good practices campaigns may be crucial to decrease risk.
Arbitragem científica: yes
ISSN: 1528-7394
Versão do Editor:
Appears in Collections:DSA - Artigos em revistas internacionais

Files in This Item:

File Description SizeFormat
2011 JTEH Solange Costa FA.pdf183,71 kBAdobe PDFView/Open
Restrict Access. You can request a copy!

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


  © 2010 - Todos os direitos reservados | Feedback Ministério da Saúde
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia