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http://hdl.handle.net/10400.18/4800| Title: | Genetic variants of CYP2C9 and IL-6 on female infertility |
| Author: | Cardoso, R. Gonçalves, A. da Silva, J.M. Oliveira, C. Xavier, P. Alves, H. Barros, A. Botelho, M.C. |
| Keywords: | Genetic Variants Female Infertility |
| Issue Date: | 8-May-2017 |
| Publisher: | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP |
| Abstract: | AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide. Within the past decades, there has been a steady rise in the treatment of female infertility with several drugs; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies used in female infertility treatments: - Interleukin-6 (IL-6) is a pleiotropic proinflammatory cytokine, highly expressed in the female urogenital tract and reproductive organs. It has been implicated in estrogen metabolism imbalance. |
| URI: | http://hdl.handle.net/10400.18/4800 |
| Appears in Collections: | DPSPDNT - Posters/abstracts em congressos nacionais |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Genetic variants of CYP2C9 and IL-6 on female infertility.pdf | 258,36 kB | Adobe PDF | View/Open |
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