Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4737
Título: Tuberculosis across the seas: CPLP-TB - a joint effort in cataloguing mycobacterium tuberculosis genetic diversity in the lusophone space
Autor: Perdigão, João
Silva, Carla
Diniz, Jaciara
Pereira, Catarina
Machado, Diana
Ramos, Jorge
da Silva, Fernanda
Brum, Clarice
Reis, Ana J.
Macedo, Maíra
Scaini, João L.
Silva, Ana B
Esteves, Leonardo
Macedo, Rita
Clemente, Sofia
Coelho, Elizabeth
Viegas, Sofia
Rabna, Paulo
Rodrigues, Amabélia
Taveira, Nuno
Jordao, Luisa
Couto, Isabel
von Groll, Andrea
Dalla-Costa, Elis R.
Rossetti, Maria Lúcia
da Silva, Pedro E. A.
Viveiros, Miguel
Portugal, Isabel
Palavras-chave: Mycobacterium tuberculosis
Tuberculosis
NGS
Portuguese Language Speaking Countries
Data: 19-Abr-2017
Resumo: The Community of Portuguese Language Speaking Countries (CPLP) comprises nine countries across four continents, accounting for 7.2% of the world’s land area, and where tuberculosis (TB) is still a cause of public health concern. A marked variation in TB incidence (23 to 551 cases per 100 000 habitants) can be observed across the different member-states and, despite of this, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and country-level geospatial distribution still exists. To address this we have gathered a comprehensive set of molecular and phenotypic drug susceptibility data on approximately 1150 different clinical isolates, from different partners, across 5 distinct portuguesespeaking countries. This initial dataset comprises molecular genotypic data obtained by either 12, 15 or 24-loci Mycobacterial Interspersed Repetitive Unit – Variable Number of Tandem repeat (MIRU-VNTR) and/or Spoligotyping. The complete dataset therefore includes M. tuberculosis clinical isolates from Portugal (n≈370), Angola (n≈80), Guinea-Bissau (n≈13), Mozambique (n≈14) and Brazil (n≈680). To make this data available to the scientific community and public health authorities we have developed CPLP-TB, an online database coupled with webbased tools that enable exploratory data analysis. This new tool specifically directed at CPLP countries include advanced data analysis capability together with graphical visualization tools (e.g. dendrogram and choropleth mapping). As a public health tool, it is expected to contribute for a deeper knowledge on the combined population structure and strain circulation between countries, thus enabling the assessment of strain specific trends in a broader macroepidemiological context. Furthermore, this new tool provides a new framework for interlaboratory cooperation on TB molecular epidemiology.
Peer review: yes
URI: http://hdl.handle.net/10400.18/4737
Versão do Editor: http://4cnmt.admeus.net/uploads/4cnmt/editor/Programa_4CNMT_060417.pdf
Aparece nas colecções:DSA - Apresentações orais em encontros internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
4CNMT-JP.pdf753,81 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.