Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4549
Título: Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015
Autor: Hurt, Aeron C.
Besselaar, Terry G.
Daniels, Rod S.
Ermetal, Burcu
Fry, Alicia
Gubareva, Larisa
Huang, Weijuan
Lackenby, Angie
Lee, Raphael T.C.
Lo, Janice
Maurer-Stroh, Sebastian
Nguyen, Ha T.
Pereyaslov, Dmitriy
Rebelo-de-Andrade, Helena
Siqueira, Marilda M.
Takashita, Emi
Tashiro, Masato
Tilmanis, Danielle
Wang, Dayan
Zhang, Wenqing
Meijer, Adam
Palavras-chave: Antiviral Resistance
Global Analysis
Influenza Virus
Neuraminidase Inhibitors
Oseltamivir
Reduced Susceptibility
Resistência aos Antimicrobianos
Data: Ago-2016
Editora: Elsevier Masson/ International Society for Antiviral Research
Citação: Antiviral Res. 2016 Aug;132:178-85. doi: 10.1016/j.antiviral.2016.06.001. Epub 2016 Jun 3
Resumo: The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections.
Peer review: yes
URI: http://hdl.handle.net/10400.18/4549
DOI: 10.1016/j.antiviral.2016.06.001
ISSN: 0166-3542
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0166354216302169
Aparece nas colecções:DDI - Artigos em revistas internacionais



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