Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4464
Título: Prevalence of microcephaly in Europe: population based study
Autor: Morris, Joan K.
Rankin, Judith
Garne, Ester
Loane, Maria
Greenlees, Ruth
Addor, Marie-Claude
Arriola, Larraitz
Barisic, Ingeborg
Bergman, Jorieke E.H.
Csaky-Szunyogh, Melinda
Dias, Carlos Matias
Draper, Elizabeth S.
Gatt, Miriam
Khoshnood, Babak
Klungsoyr, Kari
Kurinczuk, Jennifer J.
Lynch, Catherine
McDonnell, Robert
Nelen, Vera
Neville, Amanda J.
O'Mahony, Mary T.
Pierini, Anna
Randrianaivo, Hanitra
Rissmann, Anke
Tucker, David
Verellen-Dumoulin, Christine
de Walle, Hermien E.K.
Wellesley, Diana
Wiesel, Awi
Dolk, Helen
Palavras-chave: Microcefalia
Estados de Saúde e de Doença
Observação em Saúde e Vigilância
RENAC
EUROCAT
European Surveillance of Congenital Anomalies
European Surveillance
Congenital Anomalies
Europe
Data: 13-Set-2016
Editora: BMJ Publishing Group
Citação: BMJ. 2016 Sep 13;354:i4721. doi: 10.1136/bmj.i4721
Resumo: Objectives: To provide contemporary estimates of the prevalence of microcephaly in Europe, determine if the diagnosis of microcephaly is consistent across Europe, and evaluate whether changes in prevalence would be detected using the current European surveillance performed by EUROCAT (the European Surveillance of Congenital Anomalies). Design: Questionnaire and population based observational study. Setting: 24 EUROCAT registries covering 570 000 births annually in 15 countries. Participants: Cases of microcephaly not associated with a genetic condition among live births, fetal deaths from 20 weeks’ gestation, and terminations of pregnancy for fetal anomaly at any gestation. Main: outcome measures Prevalence of microcephaly (1 Jan 2003-31 Dec 2012) analysed with random effects Poisson regression models to account for heterogeneity across registries. Results: 16 registries responded to the questionnaire, of which 44% (7/16) used the EUROCAT definition of microcephaly (a reduction in the size of the brain with a skull circumference more than 3 SD below the mean for sex, age, and ethnic origin), 19% (3/16) used a 2 SD cut off, 31% (5/16) were reliant on the criteria used by individual clinicians, and one changed criteria between 2003 and 2012. Prevalence of microcephaly in Europe was 1.53 (95% confidence interval 1.16 to 1.96) per 10 000 births, with registries varying from 0.4 (0.2 to 0.7) to 4.3 (3.6 to 5.0) per 10 000 (χ2=338, df=23, I2=93%). Registries with a 3 SD cut off reported a prevalence of 1.74 per 10 000 (0.86 to 2.93) compared with those with the less stringent 2 SD cut off of 1.21 per 10 000 (0.21 to 2.93). The prevalence of microcephaly would need to increase in one year by over 35% in Europe or by over 300% in a single registry to reach statistical significance (P<0.01). Conclusions: EUROCAT could detect increases in the prevalence of microcephaly from the Zika virus of a similar magnitude to those observed in Brazil. Because of the rarity of microcephaly and discrepant diagnostic criteria, however, the smaller increases expected in Europe would probably not be detected. Clear diagnostic criteria for microcephaly must be adopted across Europe.
Descrição: Co-autor: Carlos Matias Dias - Departamento de Epidemiologia, Instituto Nacional de Saúde Doutor Ricardo Jorge
Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021822/
Peer review: yes
URI: http://hdl.handle.net/10400.18/4464
DOI: 10.1136/bmj.i4721
ISSN: 0959-8138
Versão do Editor: http://www.bmj.com/content/354/bmj.i4721
Aparece nas colecções:DEP - Artigos em revistas internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
bmj_Microcephaly_2016.pdf356,47 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.