Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4250
Título: Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study
Autor: Grundmann, Hajo
Glasner, Corinna
Albiger, Barbara
Aanensen, David M.
Tomlinson, Chris T.
Andrasević, Arjana Tambić
Cantón, Rafael
Carmeli, Yehuda
Friedrich, Alexander W.
Giske, Christian G.
Glupczynski, Youri
Gniadkowski, Marek
Livermore, David M.
Nordmann, Patrice
Poirel, Laurent
Rossolini, Gian M.
Seifert, Harald
Vatopoulos, Alkiviadis
Walsh, Timothy
Woodford, Neil
Monnet, Dominique L.
EuSCAPE Working Group
Koraqi, A..
Lacej, D.
Apfalter, P.
Hartl, R.
Glupczynski, Y.
Huang, T.D.
Strateva, T
Marteva-Proevska, Y.
Tambic, Andrasevic A.
Butic, I.
Pieridou-Bagatzouni, D.
Maikanti-Charalampous, P.
Hrabak, J.
Zemlickova, H.
Hammerum, A.
Jakobsen, L.
Ivanova, M.
Pavelkovich, A.
Jalava, J.
Österblad, M.
Dortet, L.
Vaux, S.
Kaase, M.
Gatermann, S.G.
Vatopoulos, A.
Tryfinopoulou, K.
Tóth, A.
Jánvári, L.
Boo, T.W.
McGrath, E.
Carmeli, Y.
Adler, A.
Pantosti, A.
Monaco, M.
Raka, L.
Kurti, A.
Balode, A.
Saule, M.
Miciuleviciene, J.
Mierauskaite, A.
Perrin -Weniger, M.
Reichert, P.
Nestorova, N.
Debattista, S.
Mijovic, G.
Lopicic, M.
Samuelsen, Ø.
Haldorsen, B.J.
Żabicka, D.
Literacka, E.
Caniça, M.
Manageiro, V.
Kaftandzieva, A.
Trajkovska-Dokic, E.
Damian, M.
Lixandru, B.
Jelesic, Z.
Trudic, A.
Niks, M.
Schreterova, E.
Pirs, M.
Cerar, T.
Oteo, J.
Aracil, B.
Giske, C.
Sjöström, K.
Gür, D.
Cakar, A.
Woodford, N.
Hopkins, K.
Wiuff, C.
Brown, D.J.
Palavras-chave: EuSCAPE
ECDC
Carbapenemase-producing Klebsiella pneumoniae
Carbapenemase-producing Escherichia coli
Resistência aos Antimicrobianos
Data: Fev-2017
Editora: Elsevier: Lancet
Citação: Lancet Infect Dis. 2017 Feb;17(2):153-163. doi: 10.1016/S1473-3099(16)30257-2. Epub 2016 Nov 18.
Resumo: BACKGROUND: Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. METHODS: National expert laboratories recruited hospitals with diagnostic capacities, who collected the first ten carbapenem non-susceptible clinical isolates of K pneumoniae or E coli and ten susceptible same-species comparator isolates and pertinent patient and hospital information. Isolates and data were relayed back to national expert laboratories, which made laboratory-substantiated information available for central analysis. FINDINGS: Between Nov 1, 2013, and April 30, 2014, 455 sentinel hospitals in 36 countries submitted 2703 clinical isolates (2301 [85%] K pneumoniae and 402 (15%) E coli). 850 (37%) of 2301 K pneumoniae samples and 77 (19%) of 402 E coli samples were carbapenemase (KPC, NDM, OXA-48-like, or VIM) producers. The ratio of K pneumoniae to E coli was 11:1. 1·3 patients per 10 000 hospital admissions had positive clinical specimens. Prevalence differed greatly, with the highest rates in Mediterranean and Balkan countries. Carbapenemase-producing K pneumoniae isolates showed high resistance to last-line antibiotics. INTERPRETATION: This initiative shows an encouraging commitment by all participants, and suggests that challenges in the establishment of a continent-wide enhanced sentinel surveillance for carbapenemase-producing Enterobacteriaeceae can be overcome. Strengthening infection control efforts in hospitals is crucial for controlling spread through local and national health care networks.
Descrição: The members of the European Survey on Carbapenemase-Producing Enterobacteriaceae, (EuSCAPE) Working Group are: Portugal—Manuela Caniça and Vera Manageiro
Peer review: yes
URI: http://hdl.handle.net/10400.18/4250
DOI: 10.1016/S1473-3099(16)30257-2
ISSN: 1473-3099
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S1473309916302572
Aparece nas colecções:DDI - Artigos em revistas internacionais

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