Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4209
Título: Influenza seroprotection correlates with predominant circulating viruses during 2014/15 and 2015/16 seasons in Portugal
Autor: Guiomar, Raquel
Cristóvão, Paula
Conde, Patrícia
Costa, Inês
Pechirra, Pedro
Rodrigues, Ana Paula
Pereira da Silva, Susana
Nunes, Baltazar
Mouro Pinto, Rita
Sobrinho Simões, Joana
Costa, Maria do Rosário
Guimarães, João Tiago
Rodrigues, Fernando
Correia, Lurdes
Pereira-Vaz, João
Caseiro, Paula
Cabral Veloso, Rita
Mota Vieira, Luísa
Pimentel Couto, Ana Rita
Santos, Margarida
Bruges Armas, Jácome
Branquinho, Paula
Corte-Real, Rita
Martins, Luís
Cunha, Mário
Almeida, Sofia
Viseu, Regina
Inácio, Filipe
Peres, Maria João
Milho, Luís
Fernandes, Aida
Maurílio, Manuel
Caldeira, Filomena
Sanches, Raquel
Dantas, Filipa
Freitas, Ludivina
Andrade, Graça
Mota, Paula
Palavras-chave: Infecções Respiratórias
Gripe
Estados de Saúde e de Doença
Serology
Influenza
Data: 24-Ago-2016
Resumo: BACKGROUND: Population immune profile for influenza is highly affected by circulating influenza viruses, thus changing the risk of infection for influenza. This study aims to assess influenza immunity in the Portuguese population by age groups, during 2014 and 2015 and establish a relationship between seroprotection and circulating influenza viruses in 2014/15 and 2015/16 seasons. METHODS: Two cross-sectional studies were developed based on a convenience serum sample collected in June 2014 (n=626) and July 2015 (n=675) in hospitals from mainland and Azores and Madeira.Serums equally represent all age groups. Antibody titers were evaluated by HI assay for strains recommended for seasonal influenza vaccine northern hemisphere,2014/15 and 2015/2016. Seroprevalences were estimated for each strain by age group and the association with seasonal cumulative influenza-like illness (ILI) rates for influenza virus during both seasons was analised. RESULTS: In June 2014 the highest seroprotection was observed for influenza A(H3) (39.0%; 95% CI: 36.2-43.8%) and A(H1)pdm09 (29.7; 95% CI: 26.3-33.4%), with higher levels in children 5-14 years old. In 2014/2015 a dominant circulation of influenza B/Yamagata was observed with high incidence rates in individuals under 65 years old, the ones that had lower seroprotection. Although before the start of the season high protection for A(H3) was observed, the circulation of the new drift A(H3) strains had gained an immunological advantage,in accordance with A(H3) elevated incidence rates observed during 2014/15. In July 2015 the highest seroprotection was observed for influenza B/ Yamagata (55.1%; 95% CI: 51.4-58.9%), 2.4 times the estimated 2014.This increase was even more pronounced in younger (≤ 4 years old), 6.3 times increase in 2015.This fact is in agreement with the predominant influenza B virus detected and the high ILI incidence rate observed in children during 2014/2015 epidemic. Seroprotection levels for influenza A in July 2015 were not significantly different from 2014.During 2015/16 season, influenza A(H1N1)pdm09 was predominant, with high incidence rate in < 65 year old. Influenza B/Victoria lineage,although detected at low levels increased in frequency, in agreement with the lowest level of seroprotection detected in the general population before the start of 2015/2016 season (21.8%; 95% CI: 18.7-24.0%). CONCLUSIONS There was a correlation between virus circulation, incidence rates for each age group and the previous seroprotection for seasonal influenza viruses.Our study highlights the value of measuring the serological profile for influenza to establishe risk groups for infection for which an increase preventive measures, including vaccination, should be fostered.
Descrição: Rede Portuguesa de Laboratórios para o Diagnóstico da Gripe
Peer review: no
URI: http://hdl.handle.net/10400.18/4209
Aparece nas colecções:DEP - Posters/abstracts em congressos internacionais
DDI - Posters/abstracts em congressos internacionais

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