Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4186
Título: Legionella pneumophila strain associated with the first evidence of person-to-person transmission of Legionnaires’ disease: a unique mosaic genetic backbone
Autor: Borges, Vítor
Nunes, Alexandra
Sampaio, Daniel A.
Vieira, Luís
Machado, Jorge
Simões, Maria J.
Gonçalves, Paulo
Gomes, João P.
Palavras-chave: Legionella
Legionnaires' Disease
Legionella pneumophila
Infecções Respiratórias
Data: 19-Mai-2016
Editora: Nature Publishing Group
Citação: Sci Rep. 2016 May 19;6:26261. doi: 10.1038/srep26261
Resumo: A first strong evidence of person-to-person transmission of Legionnaires' Disease (LD) was recently reported. Here, we characterize the genetic backbone of this case-related Legionella pneumophila strain ("PtVFX/2014"), which also caused a large outbreak of LD. PtVFX/2014 is phylogenetically divergent from the most worldwide studied outbreak-associated L. pneumophila subspecies pneumophila serogroup 1 strains. In fact, this strain is also from serogroup 1, but belongs to the L. pneumophila subspecies fraseri. Its genomic mosaic backbone reveals eight horizontally transferred regions encompassing genes, for instance, involved in lipopolysaccharide biosynthesis or encoding virulence-associated Dot/Icm type IVB secretion system (T4BSS) substrates. PtVFX/2014 also inherited a rare ~65 kb pathogenicity island carrying virulence factors and detoxifying enzymes believed to contribute to the emergence of best-fitted strains in water reservoirs and in human macrophages, as well as a inter-species transferred (from L. oakridgensis) ~37.5 kb genomic island (harboring a lvh/lvr T4ASS cluster) that had never been found intact within L. pneumophila species. PtVFX/2014 encodes another lvh/lvr cluster near to CRISPR-associated genes, which may boost L. pneumophila transition from an environmental bacterium to a human pathogen. Overall, this unique genomic make-up may impact PtVFX/2014 ability to adapt to diverse environments, and, ultimately, to be transmitted and cause human disease.
Peer review: yes
URI: http://hdl.handle.net/10400.18/4186
DOI: 10.1038/srep26261
ISSN: 2045-2322
Versão do Editor: http://www.nature.com/articles/srep26261
Aparece nas colecções:DGH - Artigos em revistas internacionais
DDI - Artigos em revistas internacionais

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