Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4162
Título: HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
Autor: Marques, Oriana
Rosa, Ana
Leite, Luciana
Faustino, Paula
Rêma, Alexandra
Martins da silva, Berta
Porto, Graça
Lopes, Carlos
Palavras-chave: Breast Cancer
High Iron FE
Doenças Genéticas
Metabolismo do Ferro
Modificadores Genéticos
Data: 27-Dez-2016
Editora: Springer/International Cancer Microenvironment Society
Citação: Cancer Microenviron. 2016 Dec;9(2-3):85-91. doi: 10.1007/s12307-016-0191-4. Epub 2016 Dec 27.
Resumo: The association of HFE (High Iron FE) major variants with breast cancer risk and behavior has been a matter of discussion for a long time. However, their impact on the expression of iron-related proteins in the breast cancer tissue has never been addressed. In the present study, hepcidin, ferroportin 1, transferrin receptor 1 (TfR1), and ferritin expressions, as well as tissue iron deposition were evaluated in a collection of samples from breast cancers patients and analyzed according to the patients’ HFE genotype. Within the group of patients with invasive carcinoma, those carrying the p.Cys282Tyr variant in heterozygosity presented a higher expression of hepcidin in lymphocytes and macrophages than wild-type or p.His63Asp carriers. An increased expression of TfR1 was also observed in all the cell types analyzed but only in p.Cys282Tyr/p.His63Asp compound heterozygous patients. A differential impact of the two HFE variants was further noticed with the observation of a significantly higher percentage of p.Cys282Tyr heterozygous patients presenting tissue iron deposition in comparison to p.His63Asp heterozygous. In the present cohort, no significant associations were found between HFE variants and classical clinicopathological markers of breast cancer behavior and prognosis. Although limited by a low sampling size, our results provide a new possible explanation for the previously reported impact of HFE major variants on breast cancer progression, i.e., not by influencing systemic iron homeostasis but rather by differentially modulating the local cellular expression of iron-related proteins and tissue iron deposition.
Descrição: Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264664/
Peer review: yes
URI: http://hdl.handle.net/10400.18/4162
DOI: 10.1007/s12307-016-0191-4
ISSN: 1875-2292
Versão do Editor: http://link.springer.com/article/10.1007%2Fs12307-016-0191-4
Aparece nas colecções:DGH - Artigos em revistas internacionais

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