Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/4036
Título: Molecular characterization of human T cell leukemia virus type 1 subtypes in a group of infected individuals diagnosed in Portugal and Spain
Autor: Pádua, E.
Rodés, B.
Pérez-Piñar, T.
Silva, A.F.
Jiménez, V.
Ferreira, F.
Toro, C.
Palavras-chave: HTLV-1
Infecções Sexualmente Transmissíveis
Data: Mar-2011
Editora: Mary Ann Liebert7International Retrovirology Association
Citação: AIDS Res Hum Retroviruses. 2011 Mar;27(3):317-22. doi: 10.1089/aid.2010.0195. Epub 2010 Oct 18
Resumo: Over the past decade, Portugal and Spain received large numbers of immigrants from HTLV-1 endemic areas. Our aim was to investigate the diversity of subtypes circulating in these two countries and the introduction of new variants. We performed a molecular analysis of HTLV-1 strains in patients diagnosed since 1998. LTR and env proviral sequences from 26 individuals were analyzed to generate phylogenetic trees along with reference HTLV-1 subtypes from several geographic origins. Epidemiological and clinical data were recorded. Most subjects were immigrants (57.7%) from South America and Africa. All isolates belonged to the cosmopolitan A subtype. Most carried the transcontinental subgroup A, but five subjects carried subgroup D and one carried subgroup C, previously unreported in Europe. HTLV strains showed separate clusters linked to the patients' geographic origin. Although subjects with HTLV-1 infection tend not to be engaged in high-risk practices, silent dissemination of a broad diversity of HTLV-1 viruses may still occur.
Peer review: yes
URI: http://hdl.handle.net/10400.18/4036
DOI: 10.1089/aid.2010.0195
ISSN: 0889-2229
Versão do Editor: http://online.liebertpub.com/doi/abs/10.1089/aid.2010.0195
Aparece nas colecções:DDI - Artigos em revistas internacionais

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