Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.18/3915
Título: Regulatory crosstalk by protein kinases on CFTR trafficking and activity
Autor: Farinha, Carlos M.
Swiatecka-Urban, Agnieszka
Brautigan, David L.
Jordan, Peter
Palavras-chave: Vias de Transdução de Sinal e Patologias Associadas
Protein Kinase
WNK
CFTR
Membrane Traffic
Data: Jan-2016
Editora: Frontiers Media
Citação: Front Chem. 2016 Jan 20;4:1. doi: 10.3389/fchem.2016.00001. eCollection 2016.
Resumo: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a member of the ATP binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride ion channel in fluid-transporting epithelia. There is abundant evidence that CFTR activity (i.e., channel opening and closing) is regulated by protein kinases and phosphatases via phosphorylation and dephosphorylation. Here, we review recent evidence for the role of protein kinases in regulation of CFTR delivery to and retention in the plasma membrane. We review this information in a broader context of regulation of other transporters by protein kinases because the overall functional output of transporters involves the integrated control of both their number at the plasma membrane and their specific activity. While many details of the regulation of intracellular distribution of CFTR and other transporters remain to be elucidated, we hope that this review will motivate research providing new insights into how protein kinases control membrane transport to impact health and disease.
Peer review: yes
URI: http://hdl.handle.net/10400.18/3915
DOI: 10.3389/fchem.2016.00001
ISSN: 2296-2646
Versão do Editor: http://journal.frontiersin.org/article/10.3389/fchem.2016.00001/full
Aparece nas colecções:DGH - Artigos em revistas internacionais

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